CALL FOR PAPERS Bioengineering the Lung: Molecules, Materials, Matrix, Morphology, and Mechanics Osteopontin is an endogenous modulator of the constitutively activated phenotype of pulmonary adventitial fibroblasts in hypoxic pulmonary hypertension
نویسندگان
چکیده
Adil Anwar, Min Li, Maria G. Frid, Binod Kumar, Evgenia V. Gerasimovskaya, Suzette R. Riddle, B. Alexandre McKeon, Roopa Thukaram, Barbara O. Meyrick, Mehdi A. Fini, and Kurt R. Stenmark Department of Pediatrics, University of Colorado Denver, Aurora, Colorado, Department of Surgery, University of Colorado Denver, Aurora, Colorado, and Department of Medicine, University of Colorado Denver, Aurora, Colorado; and Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee
منابع مشابه
CALL FOR PAPERS Bioengineering the Lung: Molecules, Materials, Matrix, Morphology, and Mechanics Chronic intrauterine pulmonary hypertension increases main pulmonary artery stiffness and adventitial remodeling in fetal sheep
R. Blair Dodson, Matthew R. Morgan, Csaba Galambos, Kendall S. Hunter, and Steven H. Abman Pediatric Heart Lung Center, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado; Department of Pediatrics, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado; Department of Pathology, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado; Departm...
متن کاملmiR-29a-3p attenuates hypoxic pulmonary hypertension by inhibiting pulmonary adventitial fibroblast activation.
Activation of pulmonary adventitial fibroblasts plays a key role in the pulmonary vascular remodeling in hypoxic pulmonary hypertension. Previous studies showed that miRNAs participated in the regulation of fibroblast activation. This study explored the role of miR-29 in the activation of pulmonary adventitial fibroblasts and the therapeutic potential in hypoxic pulmonary hypertension. We found...
متن کاملCALL FOR PAPERS Bioengineering the Lung: Molecules, Materials, Matrix, Morphology, and Mechanics 15-Lipoxygenase and 15-hydroxyeicosatetraenoic acid regulate intravascular thrombosis in pulmonary hypertension
Tingting Shen, Jiucheng Shi, Na Wang, Xiufeng Yu, Chen Zhang, Jing Li, Liuping Wei, Cui Ma, Xijuan Zhao, Mingming Lian, Chun Jiang, and Daling Zhu Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University (Daqing), Daqing, China; Biopharmaceutical Key Laboratory of Heilongjiang Province, Harbin Medical University, Harbin, China; and Biology Department, Georgia Sta...
متن کاملSustained Hypoxic Pulmonary Vasoconstriction in the Isolated Perfused Rat Lung: Effect of α1-adrenergic Receptor Agonist
Background: Alveolar hypoxia induces monophasic pulmonary vasoconstriction in vivo, biphasic vasoconstriction in the isolated pulmonary artery, and controversial responses in the isolated perfused lung. Pulmonary vascular responses to sustained alveolar hypoxia have not been addressed in the isolated perfused rat lung. In this study, we investigated the effect of sustained hypoxic ventilation o...
متن کاملCALL FOR PAPERS Bioengineering the Lung: Molecules, Materials, Matrix, Morphology, and Mechanics Coming to terms with tissue engineering and regenerative medicine in the lung
Prakash YS, Tschumperlin DJ, Stenmark KR. Coming to terms with tissue engineering and regenerative medicine in the lung. Am J Physiol Lung Cell Mol Physiol 309: L625–L638, 2015. First published August 7, 2015; doi:10.1152/ajplung.00204.2015.—Lung diseases such as emphysema, interstitial fibrosis, and pulmonary vascular diseases cause significant morbidity and mortality, but despite substantial ...
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